What is Malaria?

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QUESTION

what is malaria?

ANSWER

Malaria is caused by a parasite called Plasmodium, which is transmitted via the bites of infected mosquitoes. In the human body, the parasites multiply in the liver, and then infect red blood cells. Usually, people get malaria by being bitten by an infective female Anopheles mosquito. Only Anopheles mosquitoes can transmit malaria and they must have been infected through a previous blood meal taken on an infected person. When a mosquito bites an infected person, a small amount of blood is taken in which contains microscopic malaria parasites. About 1 week later, when the mosquito takes its next blood meal, these parasites mix with the mosquito’s saliva and are injected into the person being bitten.

Because the malaria parasite is found in red blood cells of an infected person, malaria can also be transmitted through blood transfusion, organ transplant, or the shared use of needles or syringes contaminated with blood. Malaria may also be transmitted from a mother to her unborn infant before or during delivery (“congenital” malaria).

Symptoms of malaria include fever and flu-like illness, including shaking chills, headache, muscle aches, and tiredness. Nausea, vomiting, and diarrhea may also occur. Malaria may cause anemia and jaundice (yellow coloring of the skin and eyes) because of the loss of red blood cells. Symptoms usually appear between 10 and 15 days after the mosquito bite. If not treated, malaria can quickly become life-threatening by disrupting the blood supply to vital organs. Infection with one type of malaria, Plasmodium falciparum, if not promptly treated, may cause kidney failure, seizures, mental confusion, coma, and death. In many parts of the world, the parasites have developed resistance to a number of malaria medicines.

Malaria and the Brain

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QUESTION

How long does it take malaria to reach your brain?

ANSWER

The process by which malaria affects the brain is complicated, and the amount of time also varies. First of all, only one species of malaria parasite is associated with the brain – this is Plasmodium falciparum, the most deadly form of malaria. It is dangerous because when it infects red blood cells, it makes them “sticky,” so that they become lodged in the small blood vessels in the body’s organs. This process is called sequestration, and results in reduced blood flow to the organs, which can result in further complications.

When infected red blood cells sequester in the brain, the result is so-called “cerebral malaria,” which can lead to impaired consciousness, coma and even death. P. falciparum reproduces rapidly, so if not treated promptly, cerebral manifestations of the infection could appear within a matter of a few days of the initial onset of malaria symptoms. The good news is that treatment is very safe and effective, especially when started early, so when malaria is suspected as the possible cause of an illness, a blood test should be performed immediately to test for malaria, and also to determine if the species is P. falciparum.

If you have taken medications for malaria, please help Malaria.com by taking our Malaria Medication Side-effects Survey: Treatment and Prophylaxis. Thank you!

Malaria Symptoms

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QUESTION

WHAT ARE THE SYMPTOMS?

ANSWER

Symptoms of malaria include fever and flu-like illness, including shaking chills, headache, muscle aches, and tiredness. Nausea, vomiting, and diarrhea may also occur. Malaria may cause anemia and jaundice (yellow coloring of the skin and eyes) because of the loss of red blood cells. Symptoms usually appear between 10 and 15 days after the mosquito bite. If not treated, malaria can quickly become life-threatening by disrupting the blood supply to vital organs. Infection with one type of malaria, Plasmodium falciparum, if not promptly treated, may cause kidney failure, seizures, mental confusion, coma, and death. In many parts of the world, the parasites have developed resistance to a number of malaria medicines.

Malaria Relapse Again and Again

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QUESTION

Hi, I have malaria, after every 2 to 3 months.  I had malaria positive when I was pregnant at 3 mnths I was hospitalized, it was P.vivax, it aggravated my pregnancy symptoms even, I had blood transfusion as Hb was 7, then aftr completion of 10 tab chloroquin course on discharge doctr advice me to take 2 tab chloroquin once a week for my whole pregnancy, I stopd taking drug at my 7 mnth as I got fed up of treatment, n hyperemesis whenevr I took chloroquin, then I had malaria in last days of my pregnancy again, it was vivax again then I had premature delivery with antepartum hemorage following c.section, after one month I had p.vivax malaria again, I am breast feeding mother, doctor again after completion of 10 tabs chloroquin advice 2 tabs chloroquin a week til I breast feed, I am fed up of taking chloroquin, its effects and malaria again and again, pls help me to ERADICATE from my blood, can I take Primaquine to help myself even I am breast feeding? And is it sure primaquine stop relapsing malaria?
I dont know why but I also had chest pain these days, I have enlarged spleen tip, Hb. 9, trophozites again in blood.
how to completely get rid of it? pls help me!

ANSWER

Thanks for your question – it sounds like you have had a very grueling time getting through these malaria episodes! I have forwarded your question to the medical experts who advise us here on malaria.com, but in the meantime I will try to at least partially answer your question.

As far as I am aware, there is not a lot of safety testing of primaquine in breast-feeding mothers. The main concern is with hemolysis, if either the mother or baby is G6PD deficient. However, I have heard of breast-feeding mothers being given primaquine in some cases, if the G6PD status of her and her baby has been determined to be normal. Primaquine, when taken for the full dosage period, is very effective at killing hypnozoites, which are the latent form of malaria that cause relapses. If you are interested in taking primaquine, you should talk to your doctor about the risks associated with taking the drug, and certainly have yourself and your infant tested for G6PD deficiency before starting treatment.

If you have taken medications for malaria, please help Malaria.com by taking our Malaria Medication Side-effects Survey: Treatment and Prophylaxis. Thank you!

Deadliest Malaria Parasite

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QUESTION

which malarial parasite is deadliest for humans, and why?

ANSWER

By far the most deadly malaria parasite is Plasmodium falciparum, as it is responsible for >95% of all malaria deaths every year. Most of these fatalities occur in young children in sub-Saharan Africa.

The causes for why P. falciparum is so deadly are still not fully understood. This parasite has the ability to cause infected red blood cells to become “sticky”, and therefore clog up small blood vessels called capillaries inside the body’s organs. This process is known as “sequestration”. Sequestration reduces blood flow to major organs, resulting in a variety of secondary conditions, perhaps the most famous well-recognized of which is so-called “cerebral malaria”, where oxygen flow to the brain is reduced and as a result of this and other effects of sequestration, impaired consciousness, coma and even death can occur.

What is Malaria?

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QUESTION

What is Malaria?

ANSWER

Malaria is a disease caused by parasites of the genus Plasmodium. Transmitted by mosquitoes, there are several different kinds of malaria distributed throughout the tropical and sub-tropical regions of the world, causing somewhere between 300-500 million cases of disease each year, and as many as 1 million deaths. In fact, malaria is one of the biggest killers of children under the age of five in sub-Saharan Africa, one of the regions of the world where the burden from malaria is the highest. Malaria is usually an acute disease, manifesting itself with severe fever, chills, headache and often nausea as well. Some types of malaria can have relapsing episodes over a time period of many years.

Having said this, malaria is easily preventable, through avoiding mosquito bites by wearing appropriate clothing and sleeping under insecticide-treated bednets, or through taking preventative medication (called prophylaxis). Malaria is also treatable once symptoms appear, through ingesting safe, effective and relatively cheap drugs. With such control measures at hand, you may ask why malaria is still such a huge problem in our world; the answer is that delivering control strategies and treatment to populations most at risk is difficult, and often countries with high malaria burdens don’t have efficient and effective health systems in place to coordinate control efforts.

International non-governmental organisations such as the World Health Organisation, as well as a multitude of non-profit organisations such as the Malaria Consortium and Malaria No More, work tirelessly to bring malaria control and treatment to the places that need it most, with the aim to eradicate malaria as a disease of public health importance.

How to Take BFMP Specimen for Malaria

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QUESTION

How to take a bfmp specimen?

ANSWER

BFMP, when relating to malaria, refer to blood films for malaria parasites. Usually, fingerprick or venous blood is collected from the patient and used to create both a thin and a thick blood film. If using venous blood, the sample should be mixed with an anticoagulant in a vacuum tube. For both thin and thick films, a drop of blood is first placed on a clean glass microscope slide. For the thin smear, take a second “spreader” slide, and place the short end at the edge of the drop of blood. Wait for the blood to seep along the whole edge of the spreader slide, then push the droplet forward quickly and smoothly to spread it thinly across the rest of the slide. For the thick film, take the corner of a second slide and use it to smear the droplet of blood into a circle of 1-2 cm diameter.

You should be able to read newsprint through it, but it should not be so large as to risk dropping off the edge of the slide. When both films have completely dried, thin films are fixed in 100% methanol before staining; thick films are not fixed. A variety of different stains can be used for detection of malaria parasites, though commonly used ones include Giemsa or eosin.

Irregular Quotidian Fever

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QUESTION

Why quotidian fever is irregular?

ANSWER

Actually, the fever cycles associated with all types of malaria can be irregular. This is particular true in the initial stages of the fever, when the merozoites (the form of the parasite that leaves the liver to infect red blood cells) from different infection broods mature at different rates.

Over a few cycles of reproduction, the maturation synchronises and the parasites burst from the red blood cells in unison, creating more regular cycles of fever (no one really knows how the malaria parasites times emergence so closely!). P. falciparum may also always exhibit irregular cycles of fever, again due to asynchronous destruction of red blood cells.

In What Countries is Malaria Found?

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QUESTION

What countries can malaria be found in?

ANSWER

Malaria is found on every continent of the world except Antartica—however, regular transmission every year mainly only occurs in Central and South America, Africa, parts of the Middle East, Asia and parts of Oceania/the Pacific Islands.

The world’s highest areas of malaria prevalence and transmission occur in sub-Saharan Africa, followed by India, south-east Asia (especially the Indo-Pacific islands, such as Papua New Guinea) and parts of Central America and northern South America.

Based on the latest available data, the top five countries reporting the most annual malaria deaths were Kenya, the Democratic Republic of Congo, Cote d’Ivoire and Burkina Faso. However, the top five countries with the highest number of malaria cases per 100,000 members of the population were Guinea, Botswana, Burundi, Zambia and Malawi.

The Solomon Islands have the highest number of malaria cases per 100,000 outside of Africa, followed by Yemen. Note that these statistics are highly dependent on quality of diagnosis, treatment and reporting!

Malaria Disorder

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QUESTION

what is the malaria disorder?

ANSWER

Malaria is caused by a parasite called Plasmodium, which is transmitted via the bites of infected mosquitoes. In the human body, the parasites multiply in the liver, and then infect red blood cells. Usually, people get malaria by being bitten by an infective female Anopheles mosquito.

Symptoms of malaria include fever and flu-like illness, including shaking chills, headache, muscle aches, and tiredness. Nausea, vomiting, and diarrhea may also occur. Malaria may cause anemia and jaundice (yellow coloring of the skin and eyes) because of the loss of red blood cells. Symptoms usually appear between 10 and 15 days after the mosquito bite. If not treated, malaria can quickly become life-threatening by disrupting the blood supply to vital organs. Infection with one type of malaria, Plasmodium falciparum, if not promptly treated, may cause kidney failure, seizures, mental confusion, coma, and death. In many parts of the world, the parasites have developed resistance to a number of malaria medicines.