Malaria Effect on Host

QUESTION

What is the effect of malaria on host?

ANSWER

In the human host, malaria can often make a person very sick, though the exact symptoms and severity of the disease depends on the type of malaria (five different kinds of malaria infect humans). Many people will have a high fever, chills, nausea and body aches. In a symptom very typical of malaria, a patient will experience cyclical fever, with periods of no fever in between, lasting between one and two days. In infections with Plasmodium falciparum, the most dangerous kind of malaria, patients may experience impaired consciousness, a sign of “cerebral malaria”, which can lead to loss of consciousness, coma and even death.

In terms of the mosquito host (more commonly called the vector), the insect does not experience “illness” in the same way as the human host, and the parasite does not seem to have a particularly negative effect on the mosquito. However, some research has shown that infection with malaria may cause a mosquito to seek out blood meals more frequently, which scientists argue is an adaptation of the malaria parasite to ensure that its life cycle is continued.

Which Malaria is Most Deadly

QUESTION

In which form of malaria is the death rate highest?

ANSWER

The most dangerous form of malaria in people is Plasmodium falciparum. It causes the most severe symptoms (for example, “cerebral malaria”) and also the most deaths. It is widespread around the world, but most deaths due to P. falciparum (and in fact, all malaria) occur in sub-Saharan Africa.

Malaria Mosquito Classification

QUESTION

What is the classification of mosquito that cause malaria?

ANSWER

The mosquitoes that cause malaria in humans (and indeed also in all other mammals) all belong to the genus Anopheles. They belong to the family Culicidae, which also includes other disease vectors such as Culex and Aedes, which transmit other diseases such as dengue virus, lymphatic filariasis, West Nile virus and Japanese encephalitis, among many others. The Culicidae are part of the Diptera, or the “true flies” which possess a pair of wings and a pair of halteres. The Diptera are part of the class Insecta, which is found within the phylum Arthropoda, in the Kingdom Animalia.

Can’t Get Rid of Malaria

QUESTION

Each and every month I am suffering from malaria ..Treatment is also going on but I am unable to get rid of it.

ANSWER

It is very unusual to be reinfected so constantly with malaria. First of all, how are you getting diagnosed? You should be getting a blood test, and not relying on symptoms only; the symptoms of malaria are very general and it could be that you are suffering from something else entirely. The two main methods for accurate diagnosis are blood smear and rapid diagnostic test. The blood smear is used throughout the world, but can sometimes miss light infections (though if you feel sick, your infection is likely heavy enough to be detected by this method). The problem is that it requires a trained technician to take the sample, prepare it properly, and read it thoroughly and accurately. In my experience, many clinics, especially if they are rushed and busy, will not take the time to read a blood slide properly, and will just diagnose malaria without looking. This is really bad! It is very important to be properly diagnosed, so you can get the correct treatment, and if you don’t have malaria, you can be diagnosed for something else. The second kind of diagnostic is a rapid diagnostic test, or RDT. This looks for antibodies to malaria in your blood, and is very sensitive and quick. In an ideal world, you should try to have both done, to cross-check the results.

The next thing is to check whether you are receiving the correct treatment for the type of malaria that you have (if you are positively diagnosed with malaria). In many parts of the world, malaria has become resistant to some of the main medications used against it. Notably, this is the case in many places with Plasmodium falciparum, the most dangerous kind of malaria, which has become resistant to chloroquine in many parts of the world, to sulfadoxine-pyrimethamine (sold as Fansidar in many places) and also to mefloquine (sold as Lariam) in some places. As such, the World Health Organisation NEVER recommends these treatments be given as first line drugs against P. falciparum malaria – instead, they recommend artemisinin-combination therapies (ACTs), such as Alu, Coartem or Duo-Cotecxin. If you have been diagnosed with P. falciparum, you must try to take these kinds of drugs first. No resistance to ACTs has been reported, so if you take the full dose correctly, as prescribed by your doctor (and check to make sure the drugs are not expired), then you should be cured of malaria.

However, treatment does not stop you from getting infected again, and this is where prevention comes it. Preventing malaria is a cornerstone of control efforts. Since malaria is transmitted by a mosquito, preventing mosquitoes from entering the house, and particularly stopping them from biting you at night, is crucial. Screening all doors and windows can help stop mosquitoes from getting in, and in high transmission areas, many people will also spray inside their houses every once in a while with insecticides to kill any lingering insects. In addition, sleeping under a long-lasting insecticide treated bednet can drastically reduce the number of mosquitoes that are able to bite you at night. If you already have a net, it may be worth re-dipping it in insecticide (usually permethrin) to make sure it is still working effectively. The mosquitoes that transmit malaria feed at night, so if you are walking around outside in the evenings or at night, it is important to try to wear long-sleeved clothing, to prevent them from accessing your skin. All of these efforts will help prevent you from getting malaria again in the future.

What is Malaria?

QUESTION

What is malaria?

What is the parasite that causes malaria?

ANSWER

Malaria is a serious and sometimes fatal disease caused by a parasite, of the genus Plasmodium, that commonly infects a certain type of mosquito (of the genus Anopheles) which feeds on humans. People who get malaria are typically very sick with high fevers, shaking chills, and flu-like illness. Four kinds of malaria parasites can infect humans: Plasmodium falciparum, P. vivax, P. ovale, P. knowlesi and P. malariae. Infection with P. falciparum, if not promptly treated, may lead to death. Although malaria can be a deadly disease, illness and death from malaria can usually be prevented.

Is Malaria a Mosquito STD?

QUESTION

Is Malaria a type of STD for mosquitoes?

ANSWER

No. Mosquitoes pick up the malaria parasite from feeding on the blood of infected humans. Since only female mosquitoes feed on blood (the males feed on nectar), male mosquitoes never get infected with the malaria parasite. The life cycle of malaria in the mosquito is also completely different than in humans, and mosquitoes have a completely different physiology and immune system to humans, so it cannot be said that they get the same disease as we observe when people get infected with malaria.

Structure and Size of Malaria

QUESTION

What is the structure and size of malaria?

ANSWER

Malaria is caused by a single celled protist of the genus Plasmodium. It undergoes a complex life cycle, involving two separate asexual reproductive stages in the vertebrate host (including humans) and sexual reproduction as well as multiplication in the insect vector (all human malaria is transmitted by mosquitoes). As such, the parasite undergoes much structural and cellular change during its lifecycle, including to its size.

In terms of structure, most of the infectious stages of Plasmodium consist of a nucleus (which contains DNA, the cell’s genetic material), a mitochondrion (used for respiration and thus producing the energy for the cell), microtubules (for moving proteins and other molecules) and an apicoplast, which is a organ unique to this group of single-celled parasites which is thought to be implicated in the invasion of host cells. The surface of the organism is covered in different proteins, some of which are used for binding to target host cells.

Malaria in Africa

QUESTION

How many in Africa have been affected by Malaria?

ANSWER

In 2010, there were approximately 174 million cases of malaria in Africa. However, some people may present with more than one case of malaria per year (especially young children), so the number of people affected is likely considerably lower. However, 90% of deaths from malaria occur in Africa, and 60% in just six countries: Nigeria, DR Congo, Burkina Faso, Mozambique, Cote d’Ivoire and Mali. The good news is that malaria mortality has dropped by 33% in Africa since 2000, which is a very encouraging trend, though the aim of organizations such as Malaria No More is to fully eliminate deaths from malaria globally by 2015.

Malaria Statistics in South Africa

QUESTION

What are the statistics of malaria in South Africa from 2002-2011 for males and females?

ANSWER

It is difficult to find statistics across time that are detailed enough to distinguish between the sexes. However, I have found a website collates information about malaria in southern Africa specifically, and this link will take you to a figure on that site which shows the number of cases for three regions of South Africa for almost the last 20 years: Malaria in Southern Africa.

Another source to look at is the World Health Organisation World Malaria Report from 2011, which for the first time, presented information on malaria cases and deaths from 99 individual countries. The website for that report, which can be freely downloaded can be accessed via this link: WHO World Malaria Report 2011.

Malaria Vaccine

QUESTION

Is there a vaccine for malaria?

ANSWER

No, as of yet there is not a vaccine available for malaria. The most promising vaccine candidate, RTS,S, which has been developed by GlaxoSmithKline, is currently undergoing Phase III trials in Africa. The trial is not due to finish until 2014, so we will have to wait until then to know how effective it is. Preliminary results, published last year, suggested that it may prevent up to 50% of malaria cases in young children, though the long term protection level is not known. Other age groups will also have to be analyzed, as well as the effect of the vaccine on malaria mortality levels.