How did malaria start?

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QUESTION:

When did malaria happen?

ANSWER:

It is believed that Plasmodium, the parasite which causes malaria in a wide variety of animals, first evolved in reptiles. Even today, reptiles are infected by species of Plasmodium that are related to those that infect humans. The parasite probably then evolved to infect birds, and then, more recently, to infect mammals. Many mammals can be infected with malaria-like parasites, but most commonly rodents (like rats and mice) and primates (including humans).

The exact origins of human malaria are less clear, and indeed, there are several different types of malaria, caused by different Plasmodium species, so it would be expected that there were different evolutionary origins for these different types. The most common and deadly form of human malaria, P. falciparum, was long believed to have crossed over about 500,000 years ago from a closely related chimpanzee malaria species called P. reichnowi, and evolved to infect humans.

However, a recent paper in Nature (Liu et al., “Origin of the human malaria parasite Plasmodium falciparum in gorillas,” in volume 467 and pages 420-425) has used molecular evidence, from almost 3000 samples and several genetic regions, has instead suggested that P. falciparum evolved from a type of malaria which is found in western lowland gorillas. However, the paper did not remark on when this cross-over might have occurred. No doubt more studies will be done on this subject in the near future, which will give us a better idea of when the first cases of truly “human” malaria might have occurred!

How Many Types of Human Malaria?

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QUESTION:

How many types of malaria infect humans?

ANSWER:

There are four main types of malaria which infect humans: Plasmodium falciparum, P. vivax, P. malariae and P. ovale. P. ovale additionally can be split into two sympatric sub-species, P. o. curtisi and P. o. wallikeri. Each of these five kinds has a subtly different life cycle which results in slight variations in symptoms and also in treatment. For more information on this, check out the Q&As on malaria symptoms and malaria treatment; CDC is also a site worth checking out.

Additionally to the four species above, there are observations of a number of other Plasmodium species being able to infect humans, although much less frequently. The most reported of these is P. knowlesi, found in SE Asia, which usually infects macaque monkeys but is capable of crossing over into humans and causing severe quotidien malaria, and may even result in death. The number of cases of P. knowlesi appears to be on the rise in some regions, although the cause of this is not quite clear. For an introduction to P. knowlesi, you should read Christina Faust’s blog.

The list of other species of Plasmodium that have been reported to infect humans (sometimes only experimentally in the lab) includes P. brasilianum, P. cynomolgi, P. eylesi, P. inui, P. rhodiani, P. schwetzi, P. semiovale, P. simium and P. tenue.

Of Macaques and Men

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Plasmodium knowlesi —a new challenge in the Roll Back Malaria Program?

Deforestation oil palm Malaysia

Oil palm plantation in Malaysia: Such land-use change may be affecting malaria transmission. Photo courtesy of Yusmar Yahaya (http://www.flickr.com/photos/leafbug/4880638055/sizes/m/)

Mention of malaria often conjures images of infants hospitalized in Africa. Although most deaths from malaria are children under 5 in sub-Saharan Africa, there are many different types of malaria that put over half of the world’s population at risk in subtropical and tropical regions worldwide.

There have historically been four species of Plasmodium parasites that cause malaria humans.  P. falciparum is the most lethal species that infects humans, whereas P. vivax is the most widespread.  P. vivax and P. ovale also cause clinical symptoms and decreased economic potential in certain regions.

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