QUESTION

What is the cause of abdominal pain in malaria?

ANSWER

Often, abdominal pain in malaria occurs in the early stages of malaria infection (first week or so) and can be caused by the rapid enlargement of the liver and spleen as they become inflamed. During malaria infection, and particularly that with Plasmodium falciparum, the most deadly and severe form of malaria, large numbers of red blood cell become sequestered in the liver and the spleen (as well as other major organs). A danger is that if the spleen becomes too enlarged, it may rupture, causing massive internal bleeding which can be incredibly dangerous to the patient, and  lethal without immediate medical attention.