Injections to Get Malaria

QUESTION

I was wondering at one time did they give people shots to get malaria and then give them like I.V.S with some kind of medicine it the i.v. to counteract it, I know that some one that had ulcers of the eye and the eye specialist sent her home to her home hospital for i.v.s as he had given her a shot so she would get MALARIA, THIS would have been years ago, I don’t understnd the concept of giving her a shot for malaria and then give orders for her to have i.v.s.

ANSWER

The only reason I can think of for someone to be given an injection which might give them malaria, and then medication (perhaps in the form of an IV) in order to cure it is if they had volunteered to participate in a clinical trial, for example to test new malaria medications.

All clinical trials have to be approved by the medical research board of the country in which they are taking place, in order to ensure they comply with ethical considerations regarding patient rights, safety, etc. Many countries have an online database where clinical trials must be posted, so the public can be kept aware of what is going on. If you have such a registry in your country, you could look up whether a malaria treatment trial was conducted around the time that your friend received the injections. Otherwise, you could contact the hospital directly and ask if they participated in any trials.

Why not create a vaccine for malaria?

QUESTION

Why not create a vaccine for malaria?

ANSWER

There are many teams of scientists working hard to try to produce a malaria vaccine. In fact, only last year, the preliminary results of a vaccine trial were published. The vaccine, called RTS,S, has been produced by GlaxoSmithKline and is in the midst of Phase III trials in Africa.

The preliminary results showed approximately a 50% reduction in malaria incidence, though it is not clear how much of that protection came from the vaccine and how much should be attributed to the vaccine adjunct (a compound given with the vaccine to boost immune responses). The preliminary results also did not include analysis of how much the vaccine prevented mortality due to malaria, and levels of protection against severe malaria appeared to be low.

However, we will have to wait until 2014 for the full and final results of the clinical trial to be made available. In the meantime, other vaccine candidates are being developed, but there are many challenges to overcome. For example, there are five different types of malaria that infect people: these differ significantly in the way they develop in the human host, and so a vaccine appropriate for one may not be effective against the others.

Most vaccine researchers are focusing on Plasmodium falciparum, the most deadly form of malaria, and a vaccine effective against this parasite would certainly do the most to reduce malaria-related mortality. However, Plasmodium vivax also causes high morbidity, particularly in Asia and the Pacific, and so should not be overlooked. Moreover, within each of these species exist different strains in different areas, each of which can be markedly different from a genetic perspective.

Finally, we do not yet fully understand the complex ways in which our immune system reacts to malaria. As such, this presents a challenge to developing an effective malaria vaccine, though many scientists are willing to address this challenge and have made big inroads in the search for a safe, effective vaccine.

Another stumbling block has been inadequate financial commitment; increased resources devoted towards vaccine development would help overcome the scientific and technical obstacles in our way. PATH, coordinating the Malaria Vaccine Initiative, mentions for example that it can cost up to half a billion dollars ($500,000,000!) to fund a vaccine through the full process of development, testing and clinical trials through to licensing.

Malaria Global Clinical Trials Review – 2011

Research and Markets has announced the addition of GlobalData’s new report “Malaria Global Clinical Trials Review, H2, 2011.”

The report provides elemental information and data relating to the clinical trials on Malaria. It includes an overview of the trial numbers and their recruitment status as per the site of trial conduction across the globe. The databook offers a preliminary coverage of disease clinical trials by their phase, trial status, prominence of the sponsors and also provides briefing pertaining to the number of trials for the key drugs for treating Malaria.

The report was built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GlobalData’s team of industry experts.

Scope

  • Data on the number of clinical trials conducted in North America, South and Central America, Europe, Middle-East and Africa and Asia-pacific and top five national contributions in each, along with the clinical trial scenario in BRIC nations
  • Clinical trial (complete and in progress) data by phase, trial status, subjects recruited and sponsor type
  • Listings of discontinued trials (suspended, withdrawn and terminated)

Benefits of the Report

  • Helps readers understand the dynamics of a particular indication in a condensed manner
  • Provides an abridged view of the performance of the trials in terms of their status, recruitment, location, sponsor type and many more
  • Provides a list of discontinued  trials across the globe
  • Provides an overview of the commercial landscape of the major Universities / Institutes / Hospitals or Companies

Report Table of Contents

  • List of Tables
  • List of Figures
  • Introduction
  • Malaria
  • Report Guidance
  • Clinical Trials by Region
  • Clinical Trials by Country
  • Top Five Countries Contributing to Clinical Trials in Asia-Pacific
  • Top Five Countries Contributing to Clinical Trials in Europe
  • Top Countries Contributing to Clinical Trials in North America
  • Top Five Countries Contributing to Clinical Trials in Middle East and Africa
  • Top Countries Contributing to Clinical Trials in Central and South America
  • Clinical Trials by BRIC Nations
  • Clinical Trials by G7 Nations
  • Clinical Trials in G7 Nations by Trial Status
  • Clinical Trials by E7 Nations
  • Clinical Trials in E7 Nations by Trial Status
  • Clinical Trials by Phase
  • In Progress Trials by Phase
  • Clinical Trials by Trial Status
  • Unaccomplished Trials of Malaria
  • Subjects Recruited Over a Period of Time
  • Prominent Sponsors
  • Top Companies Participating in Malaria Therapeutics Clinical Trials
  • Prominent Drug Comparison
  • Clinical Trial Profiles
  • Clinical Trial Overview of Top Companies
  • GlaxoSmithKline plc
  • Clinical Trial Overview of GlaxoSmithKline plc
  • Pfizer Inc.
  • Clinical Trial Overview of Pfizer Inc.
  • Sanofi
  • Clinical Trial Overview of Sanofi
  • Novartis AG
  • Clinical Trial Overview of Novartis AG
  • Sigma-Tau S.p.A.
  • Clinical Trial Overview of Sigma-Tau S.p.A.
  • IPCA Laboratories Limited
  • Clinical Trial Overview of IPCA Laboratories Limited
  • EPICENTRE Biotechnologies
  • Clinical Trial Overview of EPICENTRE Biotechnologies
  • Ranbaxy Laboratories Limited
  • Clinical Trial Overview of Ranbaxy Laboratories Limited
  • Dafra Pharma International Ltd.
  • Clinical Trial Overview of Dafra Pharma International Ltd.
  • Sanaria Inc.
  • Clinical Trial Overview of Sanaria Inc.
  • PROTO PHARMA PVT. LTD.
  • Clinical Trial Overview of PROTO PHARMA PVT. LTD.
  • CPR Pharma Services Pty Ltd
  • Clinical Trial Overview of CPR Pharma Services Pty Ltd
  • Shanghai Wanxing Bio-Pharmaceutical Co. Ltd.
  • Clinical Trial Overview of Shanghai Wanxing Bio-Pharmaceutical Co. Ltd.
  • Mepha Ltd.
  • Clinical Trial Overview of Mepha Ltd.
  • Jomaa Pharma GmbH
  • Clinical Trial Overview of Jomaa Pharma GmbH
  • Treague Ltd
  • Clinical Trial Overview of Treague Ltd
  • Crucell Holland B.V
  • Clinical Trial Overview of Crucell Holland B.V
  • Lincoln Pharmaceuticals Ltd
  • Clinical Trial Overview of Lincoln Pharmaceuticals Ltd
  • Immtech Pharmaceuticals, Inc.
  • Clinical Trial Overview of Immtech Pharmaceuticals, Inc.
  • Royal DSM N.V.
  • Clinical Trial Overview of Royal DSM N.V.
  • Clinical Trial Overview of Top Universities / Institutes / Hospitals
  • The National Institute of Allergy and Infectious Diseases
  • Clinical Trial Overview of The National Institute of Allergy and Infectious Diseases
  • University of Oxford
  • Clinical Trial Overview of University of Oxford
  • Gates Malaria Partnership
  • Clinical Trial Overview of Gates Malaria Partnership
  • Centers for Disease Control and Prevention
  • Clinical Trial Overview of Centers for Disease Control and Prevention
  • London School of Hygiene & Tropical Medicine
  • Clinical Trial Overview of London School of Hygiene & Tropical Medicine
  • Medicines for Malaria Venture (MMV)
  • Clinical Trial Overview of Medicines for Malaria Venture (MMV)
  • Institute of Tropical Medicine
  • Clinical Trial Overview of Institute of Tropical Medicine
  • University of California, San Francisco
  • Clinical Trial Overview of University of California, San Francisco
  • Drugs for Neglected Diseases initiative
  • Clinical Trial Overview of Drugs for Neglected Diseases initiative
  • Radboud University
  • Clinical Trial Overview of Radboud University
  • University of Heidelberg
  • Clinical Trial Overview of University of Heidelberg
  • University of Cape Town
  • Clinical Trial Overview of University of Cape Town
  • African Malaria Network Trust
  • Clinical Trial Overview of African Malaria Network Trust
  • Hopital Albert Schweitzer
  • Clinical Trial Overview of Hopital Albert Schweitzer
  • DBL – Centre for Health Research and Development
  • Clinical Trial Overview of DBL – Centre for Health Research and Development
  • Hospital Clinic de Barcelona
  • Clinical Trial Overview of Hospital Clinic de Barcelona
  • Institut de Recherche pour le Developpement
  • Clinical Trial Overview of Institut de Recherche pour le Developpement
  • Liverpool School of Tropical Medicine
  • Clinical Trial Overview of Liverpool School of Tropical Medicine
  • Makerere University
  • Clinical Trial Overview of Makerere University
  • Menzies School of Health Research
  • Clinical Trial Overview of Menzies School of Health Research
  • Key Clinical Profiles
  • Appendix
  • Abbreviations
  • Definitions
  • Research Methodology
  • Secondary Research
  • About GlobalData

More information: Malaria Global Clinical Trials Review, H2, 2011

Source: Business Wire